The Challenging Riddle about the Janus-Type Role of Hsp60 and Related Extracellular Vesicles and miRNAs in Carcinogenesis and the Promises of Its Solution

Hsp60 is one of the most ancient and evolutionarily conserved members chaperoning system. It typically resides within mitochondria, in which it contributes to maintaining organelle’s proteome integrity homeostasis. In last few years, has been shown that also occurs other locations, intracellularly extracellularly, including cytosol, plasma-cell membrane, extracellular vesicles (EVs). Consequently, non-canonical functions interacting partners have identified realized a hub molecule diverse networks pathways implicated, directly or indirectly, development various pathological conditions, chaperonopathies. this review, we will focus on multi-faceted role chaperonin human cancers, showing contribution intra- cancer progression, as well impact miRNA-mediated regulation carcinogenesis. There are still aspects intricate biological scenario poorly understood but ongoing research steadily providing new insights direct attention them. For instance, highlight possible applications involvement carcinogenesis not only diagnosis, specific anti-cancer therapies centered use therapeutic target agent depending its role, pro- anti-tumor.